Description

Gdp-β-L-Fucose Bis(Triethylammonium) Salt is a high-purity, chemically modified nucleotide sugar derivative, specifically the bis(triethylammonium) salt of GDP-β-L-fucose. This compound serves as a critical activated donor substrate for fucosyltransferase enzymes in the biosynthesis of fucosylated glycans and glycoconjugates. It is essential for researchers and manufacturers in glycobiology, enzymology, and pharmaceutical development, particularly for studying and producing complex carbohydrates, antibodies, and other biologics where fucose motifs play a key role in function and stability.

Application

• Enzymatic Synthesis: As a high-energy donor substrate for in vitro fucosylation reactions catalyzed by fucosyltransferases (FUTs).
• Glycobiology Research: For the study of fucosylation pathways, enzyme kinetics, and the role of fucose in cell signaling and recognition.
• Biopharmaceutical Development: In the synthesis of fucosylated monoclonal antibodies (e.g., to modulate ADCC activity) and other therapeutic glycoproteins.
• Carbohydrate Chemistry: As a building block for the chemoenzymatic construction of complex oligosaccharides and glycoconjugates.
• Diagnostic Reagent Production: For manufacturing enzyme-based assay kits used in glycosylation analysis and disease biomarker detection.
• Academic & Industrial R&D: A key reagent for laboratories investigating cancer, inflammation, and microbial pathogenesis linked to glycosylation.

Basic Information

Product Name	Gdp-β-L-Fucose Bis(Triethylammonium) Salt
CAS No.	128572-74-7
Molecular Formula	C29H57N6O16P2 (Free acid) / C41H87N6O16P2 (Bis(Triethylammonium) Salt)
Molecular Weight	~1023.11 g/mol (Bis(Triethylammonium) Salt)
Synonyms	GDP-β-L-Fucose bis(triethylammonium) salt; Guanosine 5'-(trihydrogen diphosphate) P'→5'-ester with β-L-fucopyranose, bis(triethylammonium) salt; GDP-L-Fucose, bis(triethylammonium) salt; GDP-Fucose (bis-TEA salt); β-L-Fucose GDP bis(triethylammonium) salt; Activated L-fucose donor; Fucosyltransferase substrate; GDP-β-L-Fuc bis(TEA) salt
EINECS	Contact for details

Quality Control

Our Gdp-β-L-Fucose Bis(Triethylammonium) Salt is manufactured under controlled conditions to ensure the highest standards of purity and consistency, suitable for sensitive biochemical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to stringent in-house quality protocols, and specifications can be aligned with research or cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Enzymatic)	≥ 90% (by weight)
Water Content (KF)	≤ 5.0 %
Triethylammonium Content	2.0 - 2.5 equivalents
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.