Description

(R)-tert-Butyl 2-(Tosyloxymethyl)Pyrrolidine-1-Carboxylate is a high-value, chiral pyrrolidine derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its primary commercial value lies in its role as a key building block for constructing complex, biologically active molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and process scale-up teams working on novel therapeutics, agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands and organocatalysts used in enantioselective transformations.
• Peptidomimetics & Bioactive Molecule Construction: Employed in the design and synthesis of peptidomimetics and other complex molecular architectures that mimic natural products.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new synthetic routes in process chemistry.

Basic Information

Product Name	(R)-tert-Butyl 2-(Tosyloxymethyl)Pyrrolidine-1-Carboxylate
CAS No.	128510-88-3
Molecular Formula	C18H27NO5S
Molecular Weight	369.48 g/mol
Synonyms	1-Boc-2R-(tosyloxymethyl)pyrrolidine; (R)-1-(tert-Butoxycarbonyl)-2-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine; (R)-N-Boc-2-(p-Toluenesulfonyloxymethyl)pyrrolidine; (R)-tert-Butyl 2-((4-methylphenyl)sulfonyloxy)methyl)pyrrolidine-1-carboxylate; (R)-1-Boc-2-(OTs-methyl)pyrrolidine; (2R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-2-[[(4-methylphenyl)sulfonyl]oxymethyl]pyrrolidine; (R)-Boc-2-(Tosyloxymethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-(Tosyloxymethyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.