Description

Minocycline Hydrochloride Dihydrate is a semi-synthetic, broad-spectrum tetracycline antibiotic. It is valued for its potent antibacterial activity against a wide range of Gram-positive and Gram-negative organisms, including those resistant to other tetracyclines. This compound is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the formulation of oral and injectable antibiotic medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in antibiotic capsules, tablets, and injectable solutions for human and veterinary medicine.
• Treatment of Bacterial Infections: Formulated for treating acne vulgaris, respiratory tract infections, urinary tract infections, and other infections caused by susceptible bacteria.
• Research & Development: Used as a reference standard and biochemical tool in microbiological and pharmacological research.
• Veterinary Pharmaceuticals: Incorporated into medicated feeds and treatments for bacterial diseases in livestock and companion animals.

Basic Information

Product Name	Minocycline Hydrochloride Dihydrate
CAS No.	128420-71-3
Molecular Formula	C₂₃H₂₇N₃O₇ • HCl • 2H₂O
Molecular Weight	530.0 g/mol (approx.)
Synonyms	Minocycline HCl Dihydrate; 7-Dimethylamino-6-deoxy-6-demethyltetracycline Hydrochloride Dihydrate; Minocycline Hydrochloride Hydrate; Minocin (brand name derivative); Minocycline Dihydrochloride Dihydrate; Minocycline HCl 2H₂O; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide Hydrochloride Dihydrate
EINECS	Contact for details

Quality Control

Our Minocycline Hydrochloride Dihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, with specifications typically referencing major pharmacopoeias. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC, anhydrous basis)	98.0% - 102.0%
Water Content (KF)	5.0% - 7.5%
pH (1% solution)	2.0 - 3.5
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	-160° to -175°
Bacterial Endotoxins	< 0.5 EU/mg (if for injectable use)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.