Description

Hiv Protease Substrate Iv CAS NO 128340-47-6 is a specialized synthetic peptide sequence designed for the biochemical study and inhibition of the HIV-1 protease enzyme. This compound serves as a critical tool for pharmaceutical research and development, enabling the screening and characterization of potential antiretroviral drug candidates. It is essential for researchers and developers in the fields of virology, medicinal chemistry, and high-throughput drug discovery.

Application

• HIV Protease Enzyme Assays: Primary substrate for kinetic studies, inhibition constant (Ki) determination, and enzymatic activity profiling.
• Antiviral Drug Discovery: High-throughput screening (HTS) of compound libraries to identify novel HIV-1 protease inhibitors.
• Biochemical Research: Used in academic and industrial laboratories to study the mechanism of action and substrate specificity of HIV protease.
• Diagnostic Development: A key component in the development of in vitro diagnostic tests and assays for HIV research.
• Quality Control for Inhibitors: Serves as a reference standard for validating the potency and efficacy of therapeutic protease inhibitor batches.

Basic Information

Product Name	Hiv Protease Substrate Iv
CAS No.	128340-47-6
Molecular Formula	C45H62N10O12
Molecular Weight	911.04 g/mol
Synonyms	HIV Protease Substrate IV; HIV-1 Protease Substrate; Acetyl-Thr-Ile-Nle-r-Nle-Gln-Arg-NH2; Ac-Tle-Ile-Nle-ψ[CH2NH]-Nle-Gln-Arg-NH2; Ac-Tle-Ile-Nle-ψ[CH2NH]Nle-Gln-Arg-NH2; Reduced Peptide Bond Inhibitor Substrate; HIV PR Substrate IV; H-7816 (Bachem)
EINECS	Contact for details

Quality Control

Our Hiv Protease Substrate Iv is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and related substances are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.