Description

Hiv Protease Substrate Vii CAS NO 128340-45-4 is a specialized synthetic peptide substrate designed for the biochemical study and inhibition profiling of HIV-1 protease. This compound is critical for pharmaceutical research and development, serving as a key tool for evaluating the efficacy and kinetics of potential antiretroviral drug candidates. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in antiviral drug discovery and enzymatic assay development.

Application

• HIV-1 Protease Activity Assays: Used as a specific fluorogenic or chromogenic substrate to measure protease enzyme kinetics and activity in vitro.
• Antiviral Drug Screening: Essential for high-throughput screening (HTS) platforms to identify and characterize novel HIV protease inhibitors.
• Biochemical Research: Employed in academic and industrial laboratories to study the mechanism of action, substrate specificity, and resistance mutations of HIV protease.
• Diagnostic Development: Serves as a core component in the development of enzymatic diagnostic tests and kits for HIV research.
• Enzyme Inhibition Studies: Facilitates detailed kinetic analysis (Ki, IC50 determination) for potency evaluation of inhibitor compounds.
• Quality Control for Therapeutic Proteins: Can be used in relevant assay systems to ensure the consistency and purity of biomanufactured protease enzymes.

Basic Information

Product Name	Hiv Protease Substrate Vii
CAS No.	128340-45-4
Molecular Formula	C45H62N10O11
Molecular Weight	919.04 g/mol
Synonyms	HIV Protease Substrate VII; Acetyl-Thr-Ile-Nle-r-Nle-Gln-Arg-NH2 (where r-Nle is (CH2NH) reduced bond); HIV-1 Protease Substrate VII; Acetyl-Thr-Ile-ψ[CH2NH]-Nle-Gln-Arg-NH2; Fluorogenic HIV Protease Substrate; HIV PR Substrate VII; CAS 128340-45-4; Ac-Thr-Ile-ψ[CH2NH]-Nle-Gln-Arg-NH2
EINECS	Contact for details

Quality Control

Our Hiv Protease Substrate Vii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.