Description

2'-o-Methyl-I Cep is a specialized nucleoside derivative, a key building block in oligonucleotide synthesis. This compound is essential for researchers and manufacturers developing advanced therapeutic and diagnostic agents, particularly in the fields of antisense and siRNA technologies. Its primary value lies in enabling the precise modification of nucleic acid sequences to enhance stability, specificity, and efficacy. This makes it a critical raw material for pharmaceutical R&D, biotechnology companies, and diagnostic kit producers focused on next-generation genetic medicines.

Application

• Oligonucleotide Synthesis: As a protected nucleoside phosphoramidite precursor for solid-phase synthesis of modified RNA and DNA strands.
• Antisense Therapeutics: Incorporation into antisense oligonucleotides (ASOs) to improve nuclease resistance and target binding affinity.
• siRNA & miRNA Development: Used in the synthesis of small interfering RNA (siRNA) and microRNA (miRNA) analogs for gene silencing applications.
• Diagnostic Probes: Manufacturing of labeled probes and primers for molecular diagnostics, including PCR and sequencing.
• Research Reagents: Serves as a high-purity biochemical reagent for academic and industrial research in molecular biology and medicinal chemistry.
• Pharmaceutical Intermediates: Acts as a critical intermediate in the production of active pharmaceutical ingredients (APIs) for nucleic acid-based drugs.

Basic Information

Product Name	2'-o-Methyl-I Cep
CAS No.	128219-85-2
Molecular Formula	C17H23N4O7P
Molecular Weight	426.36 g/mol
Synonyms	2'-O-Methylinosine 5'-(2-Cyanoethyl Dihydrogen Phosphate); 2'-O-Methylinosine 5'-(2-Cyanoethyl) Phosphate; 2'-O-Methyl-I CEP; 2'-O-Me-Ino-CEP; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-methoxyoxolan-2-yl]-6,9-dihydro-1H-purin-6-one 5'-(2-cyanoethyl dihydrogen phosphate); Inosine, 2'-O-methyl-, 5'-(2-cyanoethyl phosphate)
EINECS	Contact for details

Quality Control

Our 2'-o-Methyl-I Cep is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for pharmaceutical and diagnostic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.