Description

5'-O-(Dimethoxytrityl)-2'-O-Methylinosine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity building blocks for antisense oligonucleotides, siRNA, and other therapeutic nucleic acid analogs. It is primarily utilized by pharmaceutical R&D teams, CROs, and CDMOs specializing in nucleic acid chemistry and novel drug development.

Application

• Solid-Phase Oligonucleotide Synthesis: Serves as a crucial phosphoramidite precursor for the automated synthesis of modified RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used in the research and production of ASOs targeting specific mRNA sequences for therapeutic applications.
• Small Interfering RNA (siRNA) Manufacturing: A vital raw material for incorporating 2'-O-methyl modifications to enhance siRNA stability and efficacy.
• Aptamer and Diagnostic Probe Synthesis: Enables the creation of nuclease-resistant aptamers and high-specificity detection probes.
• Medicinal Chemistry & Drug Discovery: Employed in the design and synthesis of novel nucleoside-based drug candidates.
• Academic and Institutional Research: Supports fundamental studies in nucleic acid structure, function, and chemical biology.

Basic Information

Product Name	5'-O-(Dimethoxytrityl)-2'-O-Methylinosine
CAS No.	128219-84-1
Molecular Formula	C32H32N4O7
Molecular Weight	584.62 g/mol
Synonyms	5'-O-DMT-2'-O-Methylinosine; DMT-2'-O-Methylinosine; 2'-O-Methyl-5'-O-(4,4'-dimethoxytrityl)inosine; 1,9-Dihydro-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-methyloxolan-2-yl]-6H-purin-6-one; N6-Hydroxy-2'-O-methyladenosine DMT derivative; Protected 2'-O-Methylinosine
EINECS	Contact for details

Quality Control

Our 5'-O-(Dimethoxytrityl)-2'-O-Methylinosine is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality control protocols are designed to support regulatory filings for drug development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.