Description

4-Methylumbelliferyl2,3,4-Tri-o-Acetyl-A-L-Idopyranosiduronicacidmethylester is a specialized fluorogenic glycosidase substrate, a key synthetic intermediate in carbohydrate chemistry and enzymology research. This compound matters for its role as a highly sensitive probe for detecting and characterizing specific enzyme activities, particularly iduronidase and related lysosomal enzymes. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in enzyme assay development, metabolic disorder research, and drug discovery programs.

Application

• Fluorogenic Substrate for Enzyme Assays: Critical for the sensitive detection and kinetic study of α-L-iduronidase activity in research and clinical diagnostics.
• Lysosomal Storage Disorder Research: Used in biochemical assays to study Mucopolysaccharidosis I (Hurler, Scheie syndromes) and related diseases.
• Diagnostic Kit Development: Serves as a core component in the formulation of kits for newborn screening and enzymatic diagnosis.
• High-Throughput Screening (HTS): Employed in pharmaceutical research to identify potential therapeutic compounds or enzyme inhibitors.
• Biochemical Research Tool: Used to investigate glycosidase specificity, mechanism of action, and carbohydrate metabolism pathways.
• Quality Control in Biologics: Applied in the characterization of recombinant enzyme preparations for therapeutic use.

Basic Information

Product Name	4-Methylumbelliferyl2,3,4-Tri-o-Acetyl-A-L-Idopyranosiduronicacidmethylester
CAS No.	128095-52-3
Molecular Formula	C24H26O13
Molecular Weight	522.46 g/mol
Synonyms	4-MU-α-L-Idopyranosiduronic Acid Methyl Ester Triacetate; 4-Methylumbelliferyl α-L-Idopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate; α-L-Iduronidase Substrate; 4-MU-α-L-IdoA-OMe Triacetate; 4-Methylumbelliferyl-2,3,4-tri-O-acetyl-α-L-idopyranosiduronic Acid Methyl Ester; Fluorogenic Iduronidase Substrate; Iduronase Substrate
EINECS	Contact for details

Quality Control

Our 4-Methylumbelliferyl2,3,4-Tri-o-Acetyl-A-L-Idopyranosiduronicacidmethylester is produced and tested under strict quality management systems to ensure high purity, batch-to-batch consistency, and reliable performance in sensitive enzymatic assays. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may affect stability and performance. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details
Fluorogenic Activity	Functional in standard α-L-iduronidase assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.