Description

(S)-Dmt-Glycidol-C(Bz) is a high-purity, chiral glycidol derivative, a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined epoxide functionality, enabling the precise construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, especially in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Used as a chiral electrophile in nucleophilic ring-opening reactions to introduce stereocenters with high enantiomeric excess.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric transformations.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and resins where chirality or specific epoxy reactivity is required.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research laboratories.

Basic Information

Product Name	(S)-Dmt-Glycidol-C(Bz)
CAS No.	127757-40-8
Molecular Formula	C21H23NO4
Molecular Weight	353.41 g/mol
Synonyms	(S)-2,3-Epoxypropyl 3,5-dimethoxy-4-(benzyloxy)benzyl ether; (S)-Glycidyl 3,5-dimethoxy-4-(benzyloxy)benzyl ether; (S)-DMT-Glycidol benzyl ether; 1-[(3,5-Dimethoxy-4-benzyloxy)phenyl]-2(S)-glycidyl ether; 4-(Benzyloxy)-3,5-dimethoxybenzyl (S)-glycidyl ether; (S)-Epichlorohydrin DMT-Bn ether derivative
EINECS	Contact for details

Quality Control

Our (S)-Dmt-Glycidol-C(Bz) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and standard pharmacopeial tests. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.