Description

8-Bromoadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is a chemically modified, cell-permeable analog of cyclic adenosine monophosphate (cAMP) designed for advanced biochemical and pharmacological research. This compound matters as a potent and selective activator of protein kinase A (PKA), offering enhanced stability against phosphodiesterase hydrolysis compared to its non-thioated counterpart. It is primarily needed by researchers in pharmaceutical development, neuroscience, and cell signaling for studying intracellular signal transduction pathways.

Application

• Biochemical Research: As a potent and stable activator of Protein Kinase A (PKA) in cell-free systems and enzyme assays.
• Cellular Signaling Studies: To investigate cAMP-mediated pathways, including gene expression, metabolism, and ion channel regulation in various cell types.
• Neuroscience & Neuropharmacology: For exploring the role of PKA in neuronal plasticity, neurotransmitter release, and long-term potentiation (LTP).
• Cardiovascular Research: Used in studies of cardiac myocyte function, contractility, and responses to β-adrenergic stimulation.
• Drug Discovery & Screening: Serves as a critical tool compound for validating assays and screening for modulators of the cAMP/PKA pathway.
• Metabolic Disorder Research: Applied in studies of insulin secretion, gluconeogenesis, and lipid metabolism regulated by cAMP.

Basic Information

Product Name	8-Bromoadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt
CAS No.	127634-20-2
Molecular Formula	C10H10BrN5O5PS2Na
Molecular Weight	506.31 g/mol
Synonyms	8-Bromo-cAMPS, Sp-isomer, sodium salt; 8-Br-cAMPS; 8-Bromoadenosine 3',5'-cyclic monophosphorothioate, (Sp)-isomer sodium salt; 8-Bromo-cyclic adenosine monophosphorothioate; 8-Br-cAMP-thioate, Sp-isomer; Sodium (Sp)-8-bromoadenosine-3',5'-cyclic monophosphorothioate; cAMP analog, 8-bromo, thioated; Protein Kinase A activator, 8-Br-cAMPS
EINECS	Contact for details

Quality Control

Our 8-Bromoadenosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure compliance with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 90%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.