Description

Flecainide-D3 CAS NO 127413-31-4 is a high-purity, deuterium-labeled internal standard critical for ensuring analytical accuracy and reliability in quantitative bioanalysis. This stable isotope-labeled compound is essential for precise quantification of the antiarrhythmic drug flecainide in complex biological matrices using advanced techniques like LC-MS/MS. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities for method development, validation, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS Bioanalysis: Serves as a critical reference compound for the accurate quantification of flecainide in plasma, serum, and other biological samples.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development and Validation: Used as a key component in establishing and validating robust, GLP-compliant analytical methods for regulatory submissions.
• Therapeutic Drug Monitoring (TDM): Supports the development of accurate assays for monitoring flecainide levels in patient blood to optimize dosage and ensure therapeutic efficacy and safety.
• Drug Impurity Profiling and Stability Studies: Aids in the identification and quantification of potential degradation products or metabolites in drug substance and product analysis.
• Forensic and Toxicology Analysis: Provides a reliable standard for the confirmatory analysis of flecainide in forensic and clinical toxicology investigations.

Basic Information

Product Name	Flecainide-D3
CAS No.	127413-31-4
Molecular Formula	C17H17D3F6N2O3
Molecular Weight	417.37 g/mol
Synonyms	Flecainide-d3; N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide-d3; (RS)-N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide-d3; Flecainide (methyl-d3); Flecainide Internal Standard-d3; Flecainide-d3 Isotopic Label; Flecainide Stable Isotope; 2,5-Bis(2,2,2-trifluoroethoxy)-N-[(2R)-2-piperidinylmethyl]benzamide-d3
EINECS	Contact for details

Quality Control

Our Flecainide-D3 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment (≥98 atom % D), and chemical purity (typically ≥95%). Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.