Description

γ-Tetrazole-Aminopterin is a specialized chemical compound that serves as a key intermediate in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of novel therapeutic agents, particularly in the fields of oncology and targeted drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing next-generation treatments.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antifolate drugs and targeted chemotherapeutic agents.
• Biochemical Research: Used in enzymatic studies and as a tool compound for investigating folate metabolism pathways and dihydrofolate reductase (DHFR) inhibition.
• Preclinical Development: Serves as a precursor in the development and optimization of new chemical entities (NCEs) for oncology applications.
• Academic Research: Employed in university and institutional labs for studying structure-activity relationships (SAR) in medicinal chemistry projects.
• High-Purity Reference Standard: Can be supplied as a certified reference material for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Item	Details
Product Name	γ-Tetrazole-Aminopterin
CAS No.	127134-21-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoic acid tetrazolyl derivative; Aminopterin tetrazole analog; Tetrazole-Aminopterin conjugate; γ-substituted Aminopterin; Pteroylglutamic acid tetrazole analog; Research Compound 127134-21-8; Antifolate-tetrazole hybrid
EINECS	Contact for details

Quality Control

Our γ-Tetrazole-Aminopterin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.