Description

(2S,3R)-3-Hydroxy-L-Isovaline CAS NO 127126-06-1 is a non-proteinogenic amino acid derivative characterized by its specific stereochemistry at the 2 and 3 positions. This compound is a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially peptidomimetics and enzyme inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators with specific stereochemical requirements.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Peptide Chemistry: Incorporated into custom peptides to study structure-activity relationships (SAR) and enhance metabolic stability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective catalytic reactions.
• Fine Chemical Production: A precursor for the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Item	Detail
Product Name	(2S,3R)-3-Hydroxy-L-Isovaline
CAS No.	127126-06-1
Molecular Formula	C5H11NO3
Molecular Weight	133.15 g/mol
Synonyms	(2S,3R)-3-Hydroxyisovaline; L-threo-3-Hydroxyisovaline; (2S,3R)-3-Hydroxy-3-methylbutanoic acid, 2-amino-; 2-Amino-3-hydroxy-3-methylbutanoic acid (specifying L-threo); 3-Hydroxy-L-isovaline; Hiv-(L); β-Hydroxy-L-isovaline; Non-proteinogenic amino acid derivative
EINECS	Contact for details

Quality Control

Our (2S,3R)-3-Hydroxy-L-Isovaline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity (assay), enantiomeric excess, and related substances are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.