Description

H-Ala-Afc is a specialized synthetic peptide derivative, identified by CAS number 126910-31-4, that serves as a critical building block and research tool in advanced biochemical synthesis. Its primary value lies in its role as a key intermediate for the development of novel protease inhibitors and other pharmacologically active compounds. This high-purity material is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require precise and reliable chemical entities for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of targeted protease inhibitors and other therapeutic peptides.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate protease mechanisms and kinetics.
• Drug Discovery: Serves as a key scaffold in medicinal chemistry for the design and optimization of new drug candidates.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide synthesis to introduce specific functional groups.
• Proteomics & Diagnostic Development: Utilized in the development of assays and tools for studying disease biomarkers and pathways.

Basic Information

Product Name	H-Ala-Afc
CAS No.	126910-31-4
Molecular Formula	C₁₇H₂₁N₃O₅
Molecular Weight	347.37 g/mol
Synonyms	L-Alanyl-7-amino-4-trifluoromethylcoumarin; Ala-AFC; H-L-Ala-AFC; Alanine-7-Amino-4-Trifluoromethylcoumarin; 7-Amino-4-trifluoromethylcoumarin-L-alanine amide; AFC Substrate (Ala); Protease Substrate AFC (Ala); Ac-Ala-AFC (related derivative)
EINECS	Contact for details

Quality Control

Every batch of H-Ala-Afc (CAS 126910-31-4) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of purity and identity. Our quality assurance protocol includes comprehensive methods such as HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term stability, consider storage at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.