Description

Norverapamil n-B-D-Glucuronide is a key glucuronide metabolite of the calcium channel blocker verapamil. This compound is of significant importance in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism, bioanalytical method development, and the synthesis of reference standards.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for quantitative analysis in bioanalytical laboratories.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for studying the metabolic pathways, bioavailability, and clearance mechanisms of verapamil and related compounds.
• Metabolite Synthesis & Characterization: Serves as a synthetic intermediate or final product for the preparation and structural elucidation of verapamil metabolites.
• Biomarker Research: Utilized in clinical research to investigate correlations between metabolite levels and drug efficacy or safety profiles.
• Analytical Method Development: Acts as a critical standard for developing and validating HPLC, LC-MS, and other chromatographic assays in biological matrices.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring detailed metabolite identification and safety assessments.

Basic Information

Product Name	Norverapamil n-B-D-Glucuronide
CAS No.	126883-99-6
Molecular Formula	C34H48N2O12
Molecular Weight	676.75 g/mol
Synonyms	Norverapamil Glucuronide; Norverapamil β-D-Glucuronide; D-619 Glucuronide; (2S)-2-[(3S,5S)-5-{[(2S)-3,4-Dimethoxyphenethyl](methyl)amino}-3-methyl-2-oxopentyl]-5-[(2S)-2-(3,4-dimethoxyphenyl)-2-{[(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}ethyl]benzonitrile; Verapamil Metabolite M9; Norverapamil N-Glucuronide
EINECS	Contact for details

Quality Control

Our Norverapamil n-B-D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for reference materials, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.