Description

trans-3-Hydroxy Cotinine Perchlorate is a high-purity chemical reference standard and metabolite of nicotine. This compound is critical for analytical research and method development, providing a definitive benchmark for accurate quantification. It is primarily utilized by research institutions, pharmaceutical companies, and contract testing laboratories engaged in pharmacokinetic studies, forensic toxicology, and biomarker analysis related to nicotine metabolism.

Application

• Analytical Reference Standard: Primary use as a certified standard for HPLC, LC-MS, and GC-MS calibration in bioanalytical laboratories.
• Pharmacokinetic & Metabolism Research: Key metabolite for studying the absorption, distribution, metabolism, and excretion (ADME) profile of nicotine and related compounds.
• Clinical Toxicology & Forensic Analysis: Essential for the accurate identification and quantification of nicotine metabolites in biological samples (e.g., urine, blood, saliva) for exposure assessment.
• Biomarker Development: Used in the development and validation of diagnostic assays to measure nicotine intake and smoking status.
• Pharmaceutical Impurity Profiling: Serves as a known impurity or degradation product reference in the quality control of nicotine-based therapeutics (e.g., nicotine replacement therapies).
• Academic & Contract Research: Fundamental reagent for university research and CROs conducting studies on tobacco-related health effects and addiction mechanisms.

Basic Information

Product Name	trans-3-Hydroxy Cotinine Perchlorate
CAS No.	126874-95-1
Molecular Formula	C10H12N2O2 • HClO4
Molecular Weight	300.68 g/mol
Synonyms	(3R,5S)-5-Hydroxy-1-methyl-2-(3-pyridinyl)-1-pyrrolidinone Perchlorate; 3-Hydroxycotinine Perchlorate; trans-3'-Hydroxycotinine Perchlorate; 3-Hydroxycotinine HClO4; Nicotine Metabolite Perchlorate Salt; 1-Methyl-5-(3-pyridyl)-2-pyrrolidinone-3-ol Perchlorate
EINECS	Contact for details

Quality Control

Our trans-3-Hydroxy Cotinine Perchlorate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, identity confirmation (IR, NMR), and residual solvent analysis, to ensure it meets the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.