Description

β-Gal-Peg3-Azide Tetraacetate is a specialized biochemical reagent designed for advanced bioconjugation and click chemistry applications. Its core value lies in the integration of a β-galactosidase-cleavable linker with a polyethylene glycol (PEG) spacer and a terminal azide group, enabling precise, bioorthogonal labeling and controlled release strategies. This compound is essential for researchers and developers in pharmaceutical R&D, proteomics, and diagnostic assay development who require sophisticated tools for targeted drug delivery systems and biomolecule analysis.

Application

• Prodrug Synthesis: Serves as a key linker in the construction of antibody-drug conjugates (ADCs) and other targeted therapeutics, where the β-galactosidase-sensitive bond allows for site-specific drug release.
• Bioorthogonal Labeling: The terminal azide group enables efficient, copper-catalyzed or strain-promoted azide-alkyne cycloaddition (Click Chemistry) with alkyne-modified biomolecules for imaging and detection.
• Cell Surface Engineering: Used to introduce chemical handles onto cell surfaces or proteins for subsequent modification with fluorescent dyes, affinity tags, or other functional groups.
• Activity-Based Probes: Incorporated into probes for detecting enzyme activity, particularly β-galactosidase, in complex biological samples or for reporter gene assays.
• Polymer and Material Science: Acts as a functional monomer or cross-linker for creating smart, enzyme-responsive hydrogels and biomaterials.
• Diagnostic Reagents: A component in the development of sensitive diagnostic kits that utilize enzymatic cleavage for signal amplification.

Basic Information

Product Name	β-Gal-Peg3-Azide Tetraacetate
CAS No.	126765-25-1
Molecular Formula	C29H43N5O15
Molecular Weight	701.68 g/mol
Synonyms	5-((((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)-1-(13-azido-4,7,10-trioxatridecyl)-1H-1,2,3-triazole-4-carboxylic acid tetraacetate; β-Gal-PEG3-N3 Tetraacetate; Azido-PEG3-β-Galactoside Tetraacetate; 1-(13-Azido-4,7,10-trioxatridecyl)-5-(((β-D-galactopyranosyloxy)methyl)-1H-1,2,3-triazole-4-carboxylic Acid Tetraacetate; β-D-Galactopyranoside, 2-(2-(2-(4-((((2S,3R,4S,5S,6R)-3,4,5-triacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethyl 4-azidobutanoate (long-form IUPAC); Click Chemistry Reagent for β-Galactosidase Release.
EINECS	Contact for details

Quality Control

Our β-Gal-Peg3-Azide Tetraacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR for structural confirmation, and mass spectrometry for identity. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications. For custom purity grades or specific impurity profiles, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake. The compound should be handled in a well-ventilated area using appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.