Description

Senecionine Acetate is a pyrrolizidine alkaloid derivative, a compound of significant interest in biochemical and pharmacological research. Its value lies in its role as a key reference standard and intermediate for studying the metabolism, toxicity, and potential bioactivity of related natural products. This high-purity material is essential for researchers and developers in the pharmaceutical, biotechnology, and agrochemical sectors who require reliable, well-characterized compounds for analytical and investigative applications.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification and quantification of pyrrolizidine alkaloids in drug substances, herbal products, and toxicological studies.
• Metabolite Research: Serves as a crucial intermediate or metabolite analog in studies investigating the biotransformation and metabolic pathways of hepatotoxic alkaloids.
• Toxicology & Safety Assessment: Employed in in-vitro and in-vivo research models to understand the structure-activity relationships and mechanisms of toxicity associated with pyrrolizidine alkaloids.
• Analytical Method Development: Acts as a critical component for developing and validating sensitive analytical methods, such as HPLC-MS and GC-MS, for contaminant screening in food, feed, and botanical extracts.
• Biochemical Reagent: Utilized in enzymatic studies and as a substrate or inhibitor in targeted biochemical assays to explore specific biological interactions.
• Academic & Institutional Research: Supports fundamental chemical and biological research in universities and government laboratories focused on natural product chemistry and phytotoxins.

Basic Information

Product Name	Senecionine Acetate
CAS No.	126642-77-1
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	Senecionine acetate; 12-Hydroxysenecionan-11,16-dione 12-acetate; Retrorsine N-oxide acetate (related); Pyrrolizidine alkaloid acetate; (1R,4aR,7aR,13aR,13bR)-1,2,3,4,4a,7,7a,13a,13b,14-Decahydro-4,7-dihydroxy-1,6-dimethyl-11,16-dioxospiro[8H-cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-8,2'-oxiran]-4-yl acetate; Senecionine monoacetate
EINECS	Contact for details

Quality Control

Our Senecionine Acetate is manufactured under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for reference materials, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.