Description

Nicotinamide 2-Azidoadenine Dinucleotide is a chemically modified coenzyme analog designed for advanced biochemical research and bioconjugation applications. This compound is a critical reagent for photoaffinity labeling and click chemistry, enabling the study and manipulation of NAD(P)-dependent enzymes and metabolic pathways. It is essential for researchers and developers in pharmaceutical discovery, enzymology, and proteomics who require precise tools for target identification and covalent modification.

Application

• Photoaffinity Labeling: Acts as a key probe for identifying and characterizing NAD(P)-binding sites in proteins and enzymes.
• Click Chemistry Substrate: Utilized in bioorthogonal reactions (e.g., CuAAC, SPAAC) for the site-specific conjugation of biomolecules, tags, or fluorophores.
• Enzyme Mechanism Studies: Investigates the structure, function, and inhibition mechanisms of dehydrogenases, reductases, and other NAD(P)-dependent enzymes.
• Proteomics Research: Enables the enrichment and identification of protein targets involved in cellular metabolism and signaling.
• Drug Discovery: Serves as a tool compound for screening and developing novel therapeutics targeting metabolic enzymes.
• Bioconjugation & Sensor Development: Used to create functionalized surfaces, biosensors, or diagnostic assays based on NAD(P) chemistry.

Basic Information

Product Name	Nicotinamide 2-Azidoadenine Dinucleotide
CAS No.	126609-61-8
Molecular Formula	C21H26N10O14P2
Molecular Weight	728.44 g/mol
Synonyms	2-Azido-NAD; 2-Azidoadenine Nicotinamide Dinucleotide; 2-N3-NAD; NAD 2-Azide; 2-Azidoadenosine-5'-diphosphoribosylnicotinamide; 2-Azidoadenine dinucleotide; Photoactivatable NAD analog; Clickable NAD cofactor
EINECS	Contact for details

Quality Control

Our Nicotinamide 2-Azidoadenine Dinucleotide is produced under stringent quality management systems. Each batch is characterized and tested to ensure high purity and consistency for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional activity is provided with every shipment to guarantee reliable performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water or buffer
Functional Activity	Tested in standard enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.