Description

Calcium Ionophore IV is a highly selective ionophore compound designed for the controlled transport of calcium ions across biological membranes. This compound is critical for research applications requiring precise modulation of intracellular calcium concentrations, a key secondary messenger in numerous cellular processes. It is an essential tool for scientists and professionals in the fields of cell biology, neurobiology, and pharmacology, facilitating advanced studies in signal transduction, enzyme regulation, and cellular physiology.

Application

• Intracellular Calcium Signaling Research: Used as a research tool to manipulate and study calcium-dependent pathways in live cells.
• Fluorescent Calcium Indicator Calibration: Serves as a standard for validating and calibrating fluorescent dye-based calcium measurement systems (e.g., Fura-2, Fluo-4).
• Pharmacological Studies: Employed in drug discovery to investigate the effects of novel compounds on calcium channel activity and cellular response.
• Neuroscience Research: Facilitates the study of calcium's role in neurotransmitter release, synaptic plasticity, and neuronal excitability.
• Cell Physiology & Biochemistry: Aids in exploring the role of calcium in muscle contraction, cell division, apoptosis, and gene expression.
• Diagnostic Assay Development: Used in the development of in vitro diagnostic (IVD) kits and biosensors for clinical and research applications.

Basic Information

Product Name	Calcium Ionophore IV
CAS No.	126572-74-5
Molecular Formula	C29H37N3O6
Molecular Weight	523.62 g/mol
Synonyms	Calcimycin, A23187; Antibiotic A23187; Calcium Ionophore A23187; 4-Bromo-A23187; (5-Methylamino-2-((2S,3R,5S,6R,8S,9R)-3,5,9-trimethyl-8-((1R)-1-methyl-2-oxo-2-((1S,2S,6R,8S)-2,6,8-trimethylbicyclo[4.3.0]non-8-yl)ethoxy)-1,7-dioxaspiro[5.5]undecan-2-yl)-2H-benzimidazol-5-yl)methyl benzoate; Calcium Ionophore IV (4-Bromo derivative)
EINECS	Contact for details

Quality Control

Our Calcium Ionophore IV is produced under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Biological Activity	Tested in standard calcium flux assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.