Description

Vincaleukoblastine, 3-(((2-((4-Azido-2-Nitrophenyl)Amino)Ethyl)Amino)Carbonyl)-O4-Deacetyl-3-De(Methoxycarbonyl)- is a specialized, semi-synthetic derivative of the natural alkaloid vincaleukoblastine (vinblastine), designed for advanced biochemical and pharmaceutical research. This modified compound is of significant interest for its potential application as a targeted photodifinity probe or a conjugation intermediate in the development of novel antibody-drug conjugates (ADCs) and other targeted therapeutics. It is primarily utilized by research scientists and process development teams in pharmaceutical R&D, biotechnology, and academic institutions focusing on oncology drug discovery and targeted delivery systems.

Application

• Photodifinity Labeling Probe: The azido and nitroaryl groups make this derivative an effective tool for studying protein-ligand interactions and identifying binding sites of vinca alkaloids.
• Antibody-Drug Conjugate (ADC) Payload Intermediate: Serves as a key synthetic precursor for constructing potent, targeted chemotherapeutic agents by conjugating to monoclonal antibodies.
• Chemical Biology Research: Used in the development of novel chemical probes to investigate tubulin dynamics and mitosis in cancer cell lines.
• Structure-Activity Relationship (SAR) Studies: Provides a versatile scaffold for medicinal chemists to explore modifications that influence potency, selectivity, and pharmacokinetic properties.
• Preclinical Drug Development: Employed in the synthesis and evaluation of next-generation vinca alkaloid analogs with potentially improved therapeutic indices.

Basic Information

Product Name	Vincaleukoblastine, 3-(((2-((4-Azido-2-Nitrophenyl)Amino)Ethyl)Amino)Carbonyl)-O4-Deacetyl-3-De(Methoxycarbonyl)-
CAS No.	126443-96-7
Molecular Formula	C48H58N8O10
Molecular Weight	907.04 g/mol
Synonyms	Vinblastine azidoaryl derivative; 3'-N-((4-Azido-2-nitrophenyl)aminoethyl)carbamoyl-3-de(methoxycarbonyl)-4-deacetylvinblastine; Vinblastine photodifinity label; 4-Deacetyl-3-de(methoxycarbonyl)vinblastine 3'-carbamate with N-(2-aminoethyl)-4-azido-2-nitroaniline; ADC payload intermediate (vinblastine-based); VBL-ANPA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our high-purity research-grade Vincaleukoblastine derivative is manufactured under controlled conditions to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry to confirm identity, purity, and the integrity of the reactive functional groups. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support research requiring material traceable to GMP-like standards for early-stage development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive and easily oxidized; allow it to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Keep the container in a cool, dry, and well-ventilated place away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.