Description

(2'S,3R,6R)-6β-Hydroxyhyoscyamine is a high-purity tropane alkaloid derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its significance lies in its stereochemically defined structure, which is critical for producing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is essential for research and development laboratories, as well as manufacturers in the pharmaceutical and fine chemical sectors, focusing on neuropharmacology and anticholinergic agents.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of sophisticated anticholinergic and antispasmodic drugs.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and quality control of related alkaloids.
• Biochemical Research: Employed in pharmacological studies to investigate muscarinic acetylcholine receptor interactions and metabolic pathways.
• Process Development: Serves as a starting material or intermediate in the development and scale-up of new synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2'S,3R,6R)-6β-Hydroxyhyoscyamine
CAS No.	126371-43-5
Molecular Formula	C17H23NO4
Molecular Weight	305.37 g/mol
Synonyms	6β-Hydroxyhyoscyamine; 6-Hydroxyhyoscyamine; (3-endo)-6β-Hydroxyhyoscyamine; 6β-Hydroxyatropine; 6-Hydroxyatropine; (1R,3r,5S)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate
EINECS	Contact for details

Quality Control

Our (2'S,3R,6R)-6β-Hydroxyhyoscyamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assays, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.