Description

2-(5-Norborene-2,3-Dicarboximido)-1,1,3,3-Tetramethyluronium Tetrafluoroborate is a specialized peptide coupling reagent, also known as a uranium salt, valued for its high efficiency in amide bond formation. This compound is critical for driving complex organic synthesis, particularly in the preparation of peptides and other sensitive biomolecules, by minimizing racemization and improving yields. It is an essential reagent for research and development laboratories in the pharmaceutical, biotechnology, and advanced materials sectors that require reliable and high-purity synthetic building blocks.

Application

• Peptide Synthesis: A key coupling agent for the solid-phase and solution-phase synthesis of peptides and peptidomimetics.
• Pharmaceutical Intermediate Manufacturing: Used in the synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates requiring amide linkages.
• Bioconjugation: Facilitates the coupling of proteins, antibodies, or other biomolecules with labels, drugs, or polymers.
• Organic Synthesis Research: Employed in academic and industrial R&D for constructing amide bonds in complex natural products and novel organic compounds.
• Polymer Chemistry: Can be utilized in the synthesis of polyamides or other specialty polymers where controlled coupling reactions are necessary.
• Combinatorial Chemistry: Supports high-throughput synthesis platforms for generating libraries of compounds for screening.

Basic Information

Product Name	2-(5-Norborene-2,3-Dicarboximido)-1,1,3,3-Tetramethyluronium Tetrafluoroborate
CAS No.	125700-73-4
Molecular Formula	C₁₅H₂₀BF₄N₃O₃
Molecular Weight	377.15 g/mol
Synonyms	TNTU; 2-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (common misassignment); 2-(5-Norbornene-2,3-dicarboximido)-1,1,3,3-tetramethyluronium tetrafluoroborate; Norborn-5-ene-2,3-dicarboximido tetramethyluronium tetrafluoroborate; TNTU Coupling Reagent; Uranium-based Coupling Agent; Tetramethyluronium Tetrafluoroborate Derivative
EINECS	Contact for details

Quality Control

Our 2-(5-Norborene-2,3-Dicarboximido)-1,1,3,3-Tetramethyluronium Tetrafluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. Handle and store under an inert atmosphere such as nitrogen or argon for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.