Description

2-(2-Pyridon-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate is a high-purity peptide coupling reagent, specifically an HOBt-derived uranium salt, known for its efficiency in amide bond formation. This compound matters for its role in facilitating high-yield, low-racemization peptide synthesis, which is critical for producing complex pharmaceutical intermediates and active ingredients. It is primarily needed by research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in the development and scale-up of peptide-based therapeutics and other bioactive molecules.

Application

• Peptide Synthesis: As a key coupling reagent for solid-phase and solution-phase peptide synthesis, minimizing epimerization.
• Pharmaceutical Intermediate Manufacturing: For the production of peptide-based Active Pharmaceutical Ingredients (APIs) and complex organic molecules.
• Bioconjugation: Facilitating the coupling of peptides to carriers, labels, or other biomolecules in drug delivery system development.
• Combinatorial Chemistry: Used in high-throughput screening libraries for drug discovery.
• Academic & Industrial Research: A vital tool in organic synthesis laboratories for constructing challenging amide bonds.
• Fine Chemical Production: Synthesis of specialty chemicals, agrochemicals, and advanced materials requiring precise amide linkages.

Basic Information

Product Name	2-(2-Pyridon-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate
CAS No.	125700-71-2
Molecular Formula	C12H19BF4N4O
Molecular Weight	322.11 g/mol
Synonyms	HBPyU; HBPyU·BF4; 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (common misnomer for HOBt-derived salts); PyUronium Tetrafluoroborate; 1-(1H-Benzotriazol-1-yloxy)-2-pyrrolidinone-1,1,3,3-tetramethyluronium tetrafluoroborate (related compound); Peptide Coupling Reagent HBPyU; Tetramethyluronium Tetrafluoroborate Derivative; Coupling Agent for Amide Bond Formation
EINECS	Contact for details

Quality Control

Our 2-(2-Pyridon-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications like pharmaceutical research. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.