Description

2-(1H-Benzotriazole-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate is a highly effective peptide coupling reagent, commonly known as TBTU. This compound is valued for its superior reactivity and efficiency in facilitating amide bond formation, a critical step in solid-phase peptide synthesis (SPPS) and other organic transformations. It is an essential tool for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries seeking to produce peptides, peptidomimetics, and complex organic molecules with high purity and yield.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key coupling agent for the efficient and racemization-free formation of peptide bonds.
• Solution-Phase Peptide Synthesis: Used in the synthesis of longer or more complex peptide sequences in solution.
• Pharmaceutical Intermediate Production: Facilitates the synthesis of active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Bioconjugation: Employed in linking peptides to other molecules, such as proteins, dyes, or polymers, for diagnostic and therapeutic applications.
• Combinatorial Chemistry: A vital reagent in library synthesis for drug discovery and lead optimization.
• Academic and Industrial Research: A standard reagent in organic synthesis laboratories for amide and ester bond formation.

Basic Information

Item	Details
Product Name	2-(1H-Benzotriazole-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate
CAS No.	125700-67-6
Molecular Formula	C11H16BF4N5O
Molecular Weight	321.09 g/mol
Synonyms	TBTU; 2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; Benzotriazol-1-yl-oxytris(dimethylamino)phosphonium tetrafluoroborate (common misnomer); Coupling Reagent TBTU; Uronium-based coupling agent
EINECS	Contact for details

Quality Control

Our 2-(1H-Benzotriazole-1-Yl)-1,1,3,3-Tetramethyluronium Tetrafluoroborate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.