Description

2,5-Dioxopyrrolidin-1-Yl 6-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)Hexanoate is a specialized, high-purity biochemical reagent designed for peptide synthesis and bioconjugation. This compound serves as a critical Fmoc-protected active ester, enabling efficient and selective amide bond formation under mild conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and the production of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient incorporation of Fmoc-6-aminohexanoic acid (Ahx) linker, facilitating the synthesis of complex peptides.
• Bioconjugation and Labeling: For the site-specific attachment of peptides, fluorophores, or other functional groups to proteins, antibodies, or nanoparticles.
• Linker Chemistry in Drug Discovery: Used to create cleavable or stable linkers in antibody-drug conjugates (ADCs) and prodrug development.
• Surface Functionalization: Modifying materials and biosensor surfaces with peptide sequences for biomedical and diagnostic applications.
• Preparation of Peptide Antigens: Key reagent in the synthesis of peptide antigens for vaccine development and immunological studies.
• Combinatorial Chemistry Libraries: Building block for generating diverse libraries of peptide-like compounds for high-throughput screening.

Basic Information

Item	Detail
Product Name	2,5-Dioxopyrrolidin-1-Yl 6-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)Hexanoate
CAS No.	125697-63-4
Molecular Formula	C25H26N2O6
Molecular Weight	450.49 g/mol
Synonyms	Fmoc-6-Ahx-OSu; Fmoc-Aminohexanoic Acid N-Hydroxysuccinimide Ester; N-((9H-Fluoren-9-ylmethoxy)carbonyl)-6-aminohexanoic Acid Succinimidyl Ester; 6-(((9H-Fluoren-9-ylmethoxy)carbonyl)amino)hexanoic Acid 2,5-Dioxopyrrolidin-1-yl Ester; Fmoc-ε-Ahx-OSu; Fmoc-6-Aminohexanoic Acid Succinimidyl Ester; Nα-Fmoc-6-aminohexanoic acid N-succinimidyl ester; Fmoc-Ahx-OSu
EINECS	Contact for details

Quality Control

Our 2,5-Dioxopyrrolidin-1-Yl 6-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)Hexanoate is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and support your critical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.