Description

Mevalonolactone, Rs-, [5-3H] is a tritium-labeled stereoisomer of mevalonolactone, a key intermediate in the isoprenoid biosynthetic pathway. This high-specific-activity radiolabeled compound is essential for precise metabolic tracing and enzymatic studies in biochemical research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies investigating cholesterol biosynthesis, protein prenylation, and other terpenoid-related metabolic pathways.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled precursor to study the mevalonate pathway and the biosynthesis of isoprenoids, sterols, and dolichols.
• Enzyme Kinetics & Inhibition Studies: Employed in assays for HMG-CoA reductase and other downstream enzymes to evaluate potential therapeutic inhibitors.
• Biochemical Research: Serves as a critical tool for investigating the regulation of cholesterol synthesis and related disorders in cell culture and in vitro systems.
• Drug Discovery & Development: Facilitates the screening and mechanistic evaluation of novel lipid-lowering agents and anti-cancer therapeutics targeting the prenylation pathway.
• Autoradiography & Imaging: Can be used in conjunction with imaging techniques to localize metabolic activity in tissue samples.

Basic Information

Product Name	Mevalonolactone, Rs-, [5-3H]
CAS No.	125441-02-3
Molecular Formula	C6H83HO3 *
Molecular Weight	~131.1 g/mol (for unlabeled form)
Synonyms	(R)-Mevalonolactone-5-3H; (R)-3,5-Dihydroxy-3-methylpentanoic acid δ-lactone-5-3H; (R)-Mevalolactone-5-3H; D-(+)-Mevalonolactone-5-3H; Tritiated (R)-Mevalonolactone; [5-3H]-(R)-Mevalolactone; Radiolabeled Mevalonic acid lactone; RS-Mevalonolactone tritiated
EINECS	Contact for details

* Formula indicates tritium (3H) labeling at the 5-position.

Quality Control

Every batch of our radiolabeled Mevalonolactone, Rs-, [5-3H] is manufactured and handled under strict quality protocols to ensure radiochemical purity, specific activity, and chemical stability. Production adheres to cGMP guidelines where applicable for research materials. Comprehensive analysis is performed, including HPLC for chemical and radiochemical purity. A detailed Certificate of Analysis (COA) specifying batch-specific data such as purity, specific activity (Ci/mmol or GBq/mmol), concentration, solvent, and expiration date is provided with each shipment.

Storage

Preserve in the original container as supplied. Store at or below -20°C. This product is strictly light-sensitive (protect from all light exposure). For long-term storage, keep container tightly sealed in a designated, well-ventilated area for radioactive materials. Users must follow all local and international regulations for the handling and disposal of radioactive substances.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (HPLC, TLC)	Conforms to reference standard
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	10-30 Ci/mmol (370-1110 GBq/mmol) *
Concentration	1 mCi/mL (37 MBq/mL) in ethanol *
Solvent	Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.

* Typical values. Exact batch-specific values are provided on the COA.