Description

3-Phenoxazone 7-[β-D-Glucuronide] Sodium Salt is a high-purity biochemical reference standard and synthetic intermediate. This compound is critical for analytical method development and validation in pharmaceutical research, particularly for metabolite identification and quantification studies. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) research.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration of analytical instruments and validation of HPLC, LC-MS, and LC-MS/MS methods in bioanalytical laboratories.
• Metabolite Research: Serves as a key standard for the identification and quantification of glucuronidated metabolites in preclinical and clinical studies, aiding in understanding drug biotransformation pathways.
• Enzyme Activity Assays: Employed as a substrate or standard in studies investigating the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Toxicology Studies: Used in the development of assays to monitor specific phenolic metabolites and their conjugated forms in biological matrices.
• Biochemical Synthesis: Acts as a specialized intermediate in the synthetic preparation of more complex conjugated molecules for research purposes.
• Quality Control: Applied in the in-house QC of pharmaceutical manufacturers to ensure the accuracy of metabolite profiling for new drug entities.

Basic Information

Product Name	3-Phenoxazone 7-[β-D-Glucuronide] Sodium Salt
CAS No.	125440-91-7
Molecular Formula	C19H15NNaO9
Molecular Weight	424.31 g/mol
Synonyms	7-Hydroxy-3H-phenoxazin-3-one 7-β-D-glucuronide sodium salt; Phenoxazone glucuronide sodium salt; Sodium 7-β-D-glucopyranuronosyloxy-3H-phenoxazin-3-one; Resorufin glucuronide sodium salt; 7-Glucuronylresorufin sodium salt; 3H-Phenoxazin-3-one, 7-(β-D-glucopyranuronosyloxy)-, sodium salt (1:1); 7-(β-D-Glucuronosyloxy)-3H-phenoxazin-3-one sodium salt
EINECS	Contact for details

Quality Control

Our 3-Phenoxazone 7-[β-D-Glucuronide] Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for research-grade reference standards. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.