Description

5'-4-(Fluorosulfonyl)Benzoyl-8-Azidoadenosine is a specialized, bifunctional chemical reagent designed for advanced bioconjugation and crosslinking applications. Its unique structure combines a photoreactive azido group with a reactive sulfonyl fluoride moiety, enabling sequential, orthogonal labeling strategies under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and chemical biology who require precise tools for modifying biomolecules, studying protein interactions, and developing targeted therapeutics.

Application

• Bioconjugation and Protein Labeling: Used as a crosslinker to attach fluorescent dyes, affinity tags, or other probes to proteins, antibodies, and peptides via its reactive functional groups.
• Activity-Based Protein Profiling (ABPP): Serves as a key reagent for profiling enzyme activities and identifying active sites in complex biological samples.
• Proteomics Research: Facilitates the study of protein-protein interactions, post-translational modifications, and protein networks through covalent capture strategies.
• Antibody-Drug Conjugate (ADC) Development: Enables the site-specific conjugation of cytotoxic payloads to antibodies for targeted cancer therapy.
• Chemical Probe Synthesis: A critical building block for creating small molecule probes to investigate biological pathways and drug targets.
• Materials Science: Used to functionalize surfaces and nanomaterials with bioactive molecules for biosensor and diagnostic device development.

Basic Information

Product Name	5'-4-(Fluorosulfonyl)Benzoyl-8-Azidoadenosine
CAS No.	125366-29-2
Molecular Formula	C17H15FN8O6S
Molecular Weight	478.41 g/mol
Synonyms	8-Azidoadenosine 5'-[4-(fluorosulfonyl)benzoate]; 8-N3-5'-O-[4-(Fluorosulfonyl)benzoyl]adenosine; 5'-O-[4-(Fluorosulfonyl)benzoyl]-8-azidoadenosine; 8-Azido-5'-O-(4-fluorosulfonylbenzoyl)adenosine; FSBA-8-N3-Adenosine; Adenosine, 8-azido-, 5'-[4-(fluorosulfonyl)benzoate]; Sulfonyl Fluoride-Azide Crosslinker
EINECS	Contact for details

Quality Control

Our 5'-4-(Fluorosulfonyl)Benzoyl-8-Azidoadenosine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert gas such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.