Description

Methoxypolyethylene Glycol 5,000 Propionic Acid is a monofunctional, reactive PEG derivative featuring a terminal carboxylic acid group. This functionalized polymer is a crucial building block for bioconjugation and surface modification, enabling the creation of stealth coatings and targeted delivery systems. It is essential for R&D and manufacturing in the pharmaceutical, biomedical, and advanced materials sectors, where precise chemical linkage is required.

Application

• Pharmaceutical PEGylation: Conjugation to peptides, proteins, and oligonucleotides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Biomaterial Functionalization: Surface modification of medical devices, implants, and diagnostic platforms to improve biocompatibility and reduce non-specific binding.
• Drug Delivery Systems: Synthesis of prodrugs and as a key component in the fabrication of micelles, liposomes, and polymer-drug conjugates.
• Crosslinking Agent: Used in the preparation of hydrogels and polymer networks via reactions with amines or hydroxyl groups.
• Affinity Chromatography: Immobilization ligand for the purification of biomolecules.
• Diagnostic Reagents: Modification of antibodies and enzymes for use in immunoassays and biosensors.

Basic Information

Product Name	Methoxypolyethylene Glycol 5,000 Propionic Acid
CAS No.	125220-94-2
Molecular Formula	CnH2n+2O(n+2) (n~113) / CH3O-(CH2CH2O)n-CH2CH2COOH
Molecular Weight	~5,000 g/mol (nominal)
Synonyms	mPEG5000-Propionic Acid; mPEG5k-COOH; Methoxy PEG Propionic Acid (MW 5000); α-Methoxy-ω-carboxypoly(ethylene glycol); Poly(ethylene glycol) methyl ether carboxylic acid (MW 5,000); PEG Methyl Ether Carboxylic Acid; mPEG-CA (5k); 2-[2-(2-Methoxyethoxy)ethoxy]acetic acid, polyethylene glycol derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical and research applications. Each batch is characterized to confirm molecular weight distribution, functional group integrity, and purity. Certificates of Analysis (COA) are available upon request, detailing specifications such as assay, polydispersity index (PDI), and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to prevent moisture absorption. Optimal storage temperature is 2-8°C for prolonged shelf life.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Assay (COOH Content)	≥95%
Average Molecular Weight (GPC)	5,000 ± 500 Da
Polydispersity Index (PDI)	≤1.05
Methoxy Substitution	≥95%
Moisture (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.