Description

1-Palmitoyl-2-(5-Hydroxy-6,8,11,14-Eicosatetraenoyl)-Glycero-3-Phosphocholine is a specialized, high-purity phospholipid derivative, specifically a hydroxy-eicosatetraenoyl (HETE)-containing phosphatidylcholine. This compound is of significant interest in biochemical and pharmacological research due to its role as a potential precursor or analog of bioactive lipid mediators involved in cellular signaling pathways. It is primarily utilized by research institutions and pharmaceutical development companies focusing on inflammation, oxidative stress, and lipid metabolism. Our supply ensures consistent quality and reliable availability for critical research and development applications.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic studies, particularly those involving phospholipases A2 and other lipid-modifying enzymes.
• Lipidomics & Metabolomics: Serves as a critical reference compound for the identification and quantification of oxidized phospholipids in complex biological samples using LC-MS/MS.
• Cell Signaling Studies: Investigated for its role in intracellular signaling cascades related to inflammation, apoptosis, and oxidative stress responses.
• Pharmaceutical R&D: Employed in the development and screening of novel therapeutic agents targeting lipid-mediated pathways in cardiovascular and inflammatory diseases.
• Liposome Formulation: Can be incorporated into model membrane systems or liposomal drug delivery vehicles to study membrane fluidity and receptor interactions.
• Reference Standard: Provides a high-purity analytical standard for quality control in the production of related lipid-based compounds or diagnostics.

Basic Information

Product Name	1-Palmitoyl-2-(5-Hydroxy-6,8,11,14-Eicosatetraenoyl)-Glycero-3-Phosphocholine
CAS No.	125111-41-3
Molecular Formula	C45H80NO9P
Molecular Weight	810.10 g/mol
Synonyms	5-HETE-PC; 1-Palmitoyl-2-(5-HETE)-sn-glycero-3-phosphocholine; PC(16:0/5-HETE); 5-Hydroxyeicosatetraenoic Acid-containing Phosphatidylcholine; LysoPAF analog; Oxidized Phosphatidylcholine; 1-Hexadecanoyl-2-(5-hydroxyicosa-6,8,11,14-tetraenoyl)-sn-glycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-(5-HETE)-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with research-grade specifications. Certificates are available upon request and can support regulatory submissions for non-clinical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform, ethanol; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.