Description

12-((4-Azido-5-Iodo-2-Hydroxybenzoyl)Amino)Dodecanoate-Coenzyme A is a specialized, high-purity biochemical reagent designed for advanced research and development applications. This compound is critical for scientists requiring a precise chemical tool for photoaffinity labeling, metabolic pathway studies, and enzyme mechanism investigations. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and life sciences sectors for probing protein interactions and developing novel therapeutic agents.

Application

• Photoaffinity Labeling Probe: Acts as a critical reagent for covalently tagging and identifying biological targets, such as enzymes and receptors, in complex mixtures.
• Metabolic Pathway Research: Used to study fatty acid metabolism and Coenzyme A-dependent enzymatic processes in cellular systems.
• Enzyme Inhibition Studies: Serves as a substrate analog or inhibitor to investigate the active sites and mechanisms of acyl-CoA utilizing enzymes.
• Chemical Biology Tool Development: Employed in the synthesis of more complex probes for proteomics and functional genomics research.
• Pharmaceutical R&D: Supports drug discovery efforts, particularly in target identification and validation stages for metabolic diseases.
• Bioconjugation and Linker Chemistry: The azido and activated ester groups enable its use in click chemistry and other bioconjugation strategies.

Basic Information

Product Name	12-((4-Azido-5-Iodo-2-Hydroxybenzoyl)Amino)Dodecanoate-Coenzyme A
CAS No.	125108-87-4
Molecular Formula	C38H60N8O19P3S
Molecular Weight	1088.88 g/mol
Synonyms	4-Azido-5-iodo-2-hydroxy-N-[12-(sulfanyloxy)-12-oxododecyl]benzamide Coenzyme A ester; 12-((4-Azido-5-iodosalicyloyl)amino)dodecanoic acid CoA thioester; Azido-Iodo-Salicyloyl-Aminododecanoyl-CoA; Photoactivatable CoA Derivative; N-[12-(Coenzyme A-sulfanyl)-12-oxododecyl]-4-azido-5-iodo-2-hydroxybenzamide; AI-S-CoA; 125108-87-4
EINECS	Contact for details

Quality Control

Our production of 12-((4-Azido-5-Iodo-2-Hydroxybenzoyl)Amino)Dodecanoate-Coenzyme A adheres to stringent quality protocols to ensure batch-to-batch consistency and research-grade purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your critical research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.