Description

4-Tolylacetyl-Coenzyme A is a specialized biochemical reagent, a Coenzyme A derivative of 4-methylphenylacetic acid, with the CAS registry number 124924-92-1. This compound serves as a critical substrate and intermediate in enzymatic research, particularly for studying acyltransferase and synthetase activities within metabolic pathways. It is essential for researchers and manufacturers in pharmaceutical development, biochemical research, and diagnostic enzyme production who require high-purity, well-characterized cofactors.

Application

• Enzymology Research: Used as a specific substrate for studying the kinetics and mechanism of acyl-CoA utilizing enzymes.
• Metabolic Pathway Analysis: Serves as a tool compound to investigate fatty acid and xenobiotic metabolism involving CoA conjugation.
• Pharmaceutical Intermediate: Acts as a biochemical precursor in the synthesis or study of potential drug candidates targeting metabolic disorders.
• Diagnostic Kit Development: Employed in the formulation of assay kits for clinical diagnostics that measure specific enzyme activities.
• Biocatalyst Studies: Utilized in research exploring the use of enzymes for synthetic chemistry applications (biocatalysis).
• Academic Research: A key reagent for university and institutional labs focused on biochemistry, molecular biology, and chemical biology.

Basic Information

Product Name	4-Tolylacetyl-Coenzyme A
CAS No.	124924-92-1
Molecular Formula	C29H44N7O17P3S
Molecular Weight	887.68 g/mol
Synonyms	p-Tolylacetyl-Coenzyme A; 4-Methylphenylacetyl-CoA; (4-Methylphenyl)acetyl-CoA; Coenzyme A, S-(4-methylphenyl)acetate; p-Methylphenylacetyl-Coenzyme A; ToAc-CoA; 4-Tolylacetyl-CoA
EINECS	Contact for details

Quality Control

Our 4-Tolylacetyl-Coenzyme A is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation by NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For custom synthesis or specific purity requirements, our technical team is available for consultation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Tested in enzymatic assay (upon request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.