Description

3-Tolylacetyl-Coenzyme A is a specialized biochemical reagent and a key intermediate in the study of enzymatic pathways, particularly those involving acyl-CoA synthetases and transferases. Its primary value lies in enabling critical research into metabolic processes, enzyme mechanisms, and the biosynthesis of complex natural products. This high-purity compound is essential for pharmaceutical R&D, academic biochemistry laboratories, and biotechnology companies focused on metabolic engineering and drug discovery.

Application

• Enzymology Research: Serves as a substrate or intermediate for studying acyl-CoA synthetase and acyltransferase enzyme kinetics and specificity.
• Metabolic Pathway Analysis: Used in in vitro assays to investigate and map biosynthetic pathways, especially those leading to toluic acid-derived metabolites.
• Pharmaceutical Development: Acts as a crucial building block or probe in the research and development of novel therapeutic agents targeting metabolic diseases.
• Biocatalyst Screening: Employed in high-throughput screening platforms to identify and characterize novel enzymes for biocatalytic applications.
• Biomarker Discovery: Utilized as a reference standard in metabolomic studies to identify and quantify related metabolites in biological samples.
• Chemical Biology Probes: Can be used to develop activity-based probes for labeling and studying specific enzyme families in complex biological systems.

Basic Information

Product Name	3-Tolylacetyl-Coenzyme A
CAS No.	124900-43-2
Molecular Formula	C₃₂H₅₀N₇O₁₇P₃S
Molecular Weight	945.81 g/mol
Synonyms	3-Methylbenzeneacetyl-CoA; 3-Methylbenzoyl-Coenzyme A; m-Tolylacetyl-Coenzyme A; m-Toluyl-Coenzyme A; 3-Toluyl-Coenzyme A; (3-Methylphenyl)acetyl-CoA; Coenzyme A, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-(3-methylphenyl)ethanethioate
EINECS	Contact for details

Quality Control

Our 3-Tolylacetyl-Coenzyme A is manufactured under strict quality controls to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to ISO 9001 quality management principles, and our production environment is designed to meet the exacting standards required for biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot into single-use vials to minimize freeze-thaw cycles and maintain stability.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Assayed in enzymatic system (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.