Description

Cholecystokinin (25-33),2-(4-Azidosalicylamido)-1,3-Dithiopropionate(Thr(28)-Ahx(31)) is a synthetic, photoactivatable derivative of the C-terminal octapeptide fragment of cholecystokinin (CCK-8). This compound is specifically engineered for advanced biochemical research, serving as a critical tool for the covalent cross-linking and identification of CCK receptor subtypes. It is essential for pharmaceutical R&D, academic neuroscience, and metabolic research laboratories focused on studying gastrointestinal function, satiety signaling, and neuropeptide pathways.

Application

• Photoaffinity Labeling Studies: Used as a covalent probe to irreversibly bind and map the active sites of cholecystokinin receptors (CCKA and CCKB).
• Receptor Characterization: Critical for identifying, isolating, and studying the structure and distribution of CCK receptors in various tissues.
• Drug Discovery Research: Employed in high-throughput screening and mechanism-of-action studies for developing novel therapeutics targeting appetite, anxiety, and pancreatic disorders.
• Biochemical Assay Development: Serves as a key reagent in developing competitive binding assays and other in vitro diagnostic tests.
• Neuroscience & Neurochemistry: A vital tool for investigating the role of CCK as a neurotransmitter/neuromodulator in the central and peripheral nervous systems.
• Metabolic Pathway Analysis: Used in research exploring the interplay between CCK, digestive enzyme secretion, gallbladder contraction, and gut-brain axis signaling.

Basic Information

Product Name	Cholecystokinin (25-33),2-(4-Azidosalicylamido)-1,3-Dithiopropionate(Thr(28)-Ahx(31))
CAS No.	124894-89-9
Molecular Formula	C58H78N14O16S2
Molecular Weight	1291.45 g/mol
Synonyms	CCK-8, Azidoaryl CCK Derivative; [Thr28,Ahx31]CCK(25-33) 2-(4-Azidosalicylamido)-1,3-Dithiopropionate; CCK (25-33) Photoaffinity Label; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2 derivative; Sandoz 208-912 photoaffinity analog; Cholecystokinin Octapeptide (CCK-8) Photoactivatable Probe; CCK Receptor Cross-linking Agent
EINECS	Contact for details

Quality Control

This high-purity biochemical reagent is manufactured under controlled conditions to ensure batch-to-batch consistency and reliability for sensitive research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, MS, and NMR to confirm identity, purity, and correct structure. Certificates of Analysis (COA) detailing purity, peptide content, and performance data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.