Description

Poly(Deoxyguanosyl-5-Ethyldeoxycytidine) is a synthetic oligonucleotide analog, a key building block in advanced nucleic acid research and development. This compound is crucial for studying DNA structure, function, and for the development of novel therapeutic agents and diagnostic tools. It is primarily utilized by research institutions and pharmaceutical companies engaged in molecular biology, genetic engineering, and the creation of next-generation oligonucleotide-based drugs.

Application

• Oligonucleotide Synthesis: Serves as a modified nucleoside phosphoramidite precursor for the solid-phase synthesis of custom DNA strands.
• Antisense & Gene Therapy Research: Used in the development of antisense oligonucleotides (ASOs) and other gene-silencing therapeutics targeting specific genetic sequences.
• Molecular Probes & Diagnostics: Acts as a component in the design of highly specific probes for PCR, sequencing, and fluorescence in situ hybridization (FISH) applications.
• Structural Biology Studies: Employed to investigate the effects of base modification on DNA duplex stability, conformation, and protein-DNA interactions.
• Apitamer Development: Utilized in SELEX (Systematic Evolution of Ligands by Exponential Enrichment) processes to create novel aptamers with enhanced binding properties.
• Bioconjugation & Labeling: Provides a reactive handle for attaching reporter molecules, such as fluorophores or quenchers, to oligonucleotides.

Basic Information

Product Name	Poly(Deoxyguanosyl-5-Ethyldeoxycytidine)
CAS No.	124873-58-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5-Ethyl-2'-deoxycytidylyl-(3'→5')-2'-deoxyguanosine; d(G-5-Et-dC); Poly(dG-dC) ethylated variant; Oligonucleotide containing 5-ethyldeoxycytidine; Deoxyguanosine-deoxy-5-ethylcytidine copolymer; 5-Ethyl-dC containing dinucleotide; DNA duplex with ethylated cytosine
EINECS	Contact for details

Quality Control

Our Poly(Deoxyguanosyl-5-Ethyldeoxycytidine) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and mass spectrometry for identity confirmation, to ensure it meets the exacting standards required for critical research applications. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.