Description

n-(n-(4-Deoxy-4-Amino-10-Methylpteroyl)-4-Fluoroglutamyl)-γ-Glutamate is a high-purity, complex folate analog with significant research and pharmaceutical development potential. This compound matters for its role as a key intermediate or reference standard in the synthesis and study of novel antifolate agents, which are critical in targeted cancer therapies. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced antifolate chemotherapeutic agents.
• Biochemical Research: Used as a reference standard or inhibitor in enzymatic studies related to folate metabolism and one-carbon transfer pathways.
• Oncology Drug Discovery: Acts as a key precursor or analog in the development of targeted therapies for cancer treatment.
• Analytical Standard: Employed in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) for method development and quality control of related compounds.
• Mechanistic Studies: Utilized in research to investigate drug resistance mechanisms and the structure-activity relationships (SAR) of folate antagonists.

Basic Information

Product Name	n-(n-(4-Deoxy-4-Amino-10-Methylpteroyl)-4-Fluoroglutamyl)-γ-Glutamate
CAS No.	124716-15-0
Molecular Formula	C26H30FN9O8
Molecular Weight	615.57 g/mol
Synonyms	4-Fluoro-10-methylpteroyl-γ-glutamate; 4-Fluoro-10-methyl-Pte-γ-Glu; 4-Deamino-4-fluoro-10-methylpteroyl-γ-glutamic acid; 10-Methyl-4-fluoropteroyl-γ-glutamate; Antifolate glutamate analog; γ-Glutamyl-4-fluoro-10-methylpteroate; Pteroyl-4-fluoro-γ-glutamate derivative
EINECS	Contact for details

Quality Control

Our n-(n-(4-Deoxy-4-Amino-10-Methylpteroyl)-4-Fluoroglutamyl)-γ-Glutamate is manufactured under strict quality systems suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure consistency and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.