Description

n-[4-[4-[(2,6-Diamino-1,4-Dihydro-4-Oxopyrimidin)-5-Yl]Butyl]Benzoyl]-L-Glutamic Acid is a high-purity, non-natural folate analog with significant biochemical research and pharmaceutical development applications. This compound matters as a key intermediate or reference standard in the synthesis and study of novel antifolate agents, which are crucial in targeted cancer therapies and other disease treatments. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on oncology, metabolic pathway analysis, and advanced therapeutic development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antifolate drugs and targeted therapeutic agents.
• Biochemical Research: Used as a reference standard or inhibitor in studies of folate metabolism, enzyme kinetics, and cellular pathways.
• Oncology Research: Investigated for its potential role in developing chemotherapeutic agents that target specific cancer cell mechanisms.
• Analytical Standard: Employed as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for quality control and method validation.
• Academic & Institutional R&D: Utilized in universities and research institutes for fundamental studies in medicinal chemistry and molecular biology.
• Preclinical Development: Supports early-stage drug discovery programs for metabolic and proliferative diseases.

Basic Information

Product Name	n-[4-[4-[(2,6-Diamino-1,4-Dihydro-4-Oxopyrimidin)-5-Yl]Butyl]Benzoyl]-L-Glutamic Acid
CAS No.	124656-55-9
Molecular Formula	C₂₀H₂₅N₅O₆
Molecular Weight	431.45 g/mol
Synonyms	5-[4-[4-[(2,6-Diamino-4-oxo-1,4-dihydropyrimidin-5-yl)butyl]benzoyl]amino]-5-oxopentanoic acid; L-Glutamic acid, N-[4-[4-[(2,6-diamino-1,4-dihydro-4-oxopyrimidin-5-yl)butyl]benzoyl]-; Folate analog intermediate; Antifolate precursor; 124656-55-9; Pteroic acid derivative; Non-natural folate
EINECS	Contact for details

Quality Control

Our n-[4-[4-[(2,6-Diamino-1,4-Dihydro-4-Oxopyrimidin)-5-Yl]Butyl]Benzoyl]-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting traceability and regulatory compliance for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.