Description

tert-Butyl (6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Hexyl)Carbamate is a high-purity, bifunctional organic building block that combines a maleimide-reactive group with a Boc-protected amine. This compound is critical for researchers and manufacturers requiring precise, site-specific conjugation and controlled amine deprotection in synthetic workflows. It is primarily utilized in the development of advanced pharmaceuticals, bioconjugates, and sophisticated polymer materials where reliable chemical linkage and functional group orthogonality are paramount.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics via maleimide-thiol coupling chemistry.
• Bioconjugation Reagent: Used for labeling peptides, proteins, and oligonucleotides with fluorescent dyes, drugs, or other payloads, facilitated by the acid-labile Boc protecting group.
• Polymer Chemistry: Serves as a functional monomer or cross-linker in the production of smart hydrogels, drug delivery systems, and functionalized polymeric scaffolds.
• Proteomics Research: Employed in the design of activity-based probes (ABPs) and affinity tags for studying enzyme function and protein-protein interactions.
• Material Science: Enables the surface functionalization of nanoparticles and other nanomaterials to impart specific biological activity or targeting capabilities.
• Combinatorial Chemistry: A valuable building block in solid-phase and solution-phase synthesis for creating diverse compound libraries with cleavable linkers.

Basic Information

Product Name	tert-Butyl (6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Hexyl)Carbamate
CAS No.	124529-64-2
Molecular Formula	C15H24N2O4
Molecular Weight	296.36 g/mol
Synonyms	1-Boc-6-maleimidohexylamine; N-Boc-6-maleimidohexylamine; 6-Maleimidohexylcarbamic Acid tert-Butyl Ester; 1-(6-((tert-Butoxycarbonyl)amino)hexyl)-1H-pyrrole-2,5-dione; Boc-NH-C6-Maleimide; Boc-6-Aminohexyl Maleimide; N-(6-((tert-Butoxycarbonyl)amino)hexyl)maleimide; Maleimide-PEG6-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl (6-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Hexyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.