Description

2-((4-Bromo-2,3-Dioxobutyl)Thio)-Adenosine 3'5'-Cyclic Monophosphate is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), designed as a potent and cell-permeable activator of protein kinase A (PKA). This compound matters for researchers as it provides a powerful tool for the targeted study of cAMP/PKA signaling pathways in cellular and biochemical assays. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on signal transduction, metabolic studies, and drug discovery.

Application

• Biochemical Research: As a potent, membrane-permeable activator of Protein Kinase A (PKA) for studying intracellular signaling cascades.
• Cell Biology Studies: Investigation of cAMP-mediated processes such as gene expression, metabolism, and cell proliferation/differentiation.
• Drug Discovery & Pharmacology: Used as a reference compound or tool molecule for screening and validating new therapeutic agents targeting the PKA pathway.
• Enzyme Kinetics: Serves as a substrate analog or activator in enzymatic assays to study PKA kinetics and inhibition.
• Neuroscience Research: Exploration of the role of cAMP and PKA in neuronal function, synaptic plasticity, and memory formation.
• Metabolic Pathway Analysis: Probing the regulation of metabolic enzymes and pathways controlled by PKA phosphorylation.

Basic Information

Product Name	2-((4-Bromo-2,3-Dioxobutyl)Thio)-Adenosine 3'5'-Cyclic Monophosphate
CAS No.	124357-33-1
Molecular Formula	C₁₄H₁₅BrN₅O₈PS
Molecular Weight	532.24 g/mol
Synonyms	2-((4-Bromo-2,3-dioxobutyl)thio)-cAMP; 2-((4-Bromo-2,3-dioxobutyl)thio)adenosine 3',5'-cyclic monophosphate; 2-((4-Bromo-2,3-dioxobutyl)thio)-Adenosine cyclic 3',5'-(hydrogen phosphate); 8-Br-cAMP derivative; Bt2-cAMP analog; Protein Kinase A Activator; cAMP, 2-((4-bromo-2,3-dioxobutyl)thio)-; 124357-33-1
EINECS	Contact for details

Quality Control

Our 2-((4-Bromo-2,3-Dioxobutyl)Thio)-Adenosine 3'5'-Cyclic Monophosphate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.