Description

Alkyne-Pegn-Alkyne 2K, 5K, 10K, 20K is a bifunctional polyethylene glycol (PEG) derivative featuring terminal alkyne groups at both ends of a precisely defined polymer chain. This compound is essential for advanced bioconjugation and materials science, enabling robust, site-specific linking of molecules via click chemistry reactions such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is primarily needed by researchers and manufacturers in pharmaceutical development, biotech, nanotechnology, and polymer chemistry for creating functionalized surfaces, cross-linked hydrogels, and targeted drug delivery systems.

Application

• Bioconjugation Linker: For creating stable PEGylated therapeutics, antibodies, and proteins.
• Click Chemistry Scaffold: As a core building block in CuAAC reactions to synthesize complex macromolecular architectures.
• Hydrogel Formation: Cross-linking agent for creating biocompatible PEG-based hydrogels for tissue engineering and drug release.
• Surface Functionalization: Modifying nanoparticles, chips, or diagnostic devices with alkyne groups for subsequent bio-immobilization.
• Polymer Synthesis: As a macro-initiator or chain extender in the synthesis of block copolymers and functional materials.
• Diagnostic Probe Development: Conjugation of imaging agents or fluorescent dyes to targeting molecules.
• ADC (Antibody-Drug Conjugate) Platform: Facilitating the development of next-generation ADCs with controlled drug-to-antibody ratios.

Basic Information

Product Name	Alkyne-Pegn-Alkyne 2K, 5K, 10K, 20K
CAS No.	124238-56-8
Molecular Formula	C2n+4H4n+6On+1 (n represents PEG repeat units)
Molecular Weight	~2000, ~5000, ~10000, ~20000 g/mol (nominal)
Synonyms	α,ω-Bis(propiolyl) PEG; Bis-Alkyne PEG; Di-Alkyne Polyethylene Glycol; PEG-Dialkyne; Alkyne-PEG-Alkyne; Propargyl-PEG-Propargyl; Poly(ethylene glycol) bis(propiolate); Bifunctional Alkyne-Terminated PEG
EINECS	Contact for details

Quality Control

Our Alkyne-Pegn-Alkyne products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with research-grade standards. Each lot is characterized to confirm critical parameters such as molecular weight distribution, degree of functionalization, and purity. Certificates of Analysis (COA) detailing specifications and test results (including NMR, HPLC, and functional group analysis) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Molecular Weight (Nominal)	2,000 / 5,000 / 10,000 / 20,000 Da
Purity (HPLC)	≥ 95%
Alkyne Functionalization	≥ 90%
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.