Description

1-Palmitoyl-2-(10-(4-((Trifluoro-Methyl)Diazirinyl)Phenyl)-9-Oxaundecanoyl)-Sn-Glycero-3-Phosphocholine is a highly specialized, photoactivatable phospholipid derivative designed for advanced biomembrane research. Its core value lies in the diazirine and trifluoromethylphenyl moieties, which enable efficient covalent cross-linking upon UV irradiation, allowing for the precise capture and analysis of transient protein-lipid interactions. This compound is essential for researchers in structural biology, drug discovery, and proteomics who require high-purity, functionalized lipids to study membrane protein dynamics and lipid signaling pathways. CAS No. 124199-66-2.

Application

• Photoaffinity Labeling (PAL): Primary application for covalently tagging and identifying lipid-binding proteins within complex biological membranes upon UV light activation.
• Membrane Protein Research: Used to probe the lipid microenvironment and interaction sites of integral membrane proteins, such as G-protein coupled receptors (GPCRs) and transporters.
• Lipidomics and Proteomics: Enables the isolation and mass spectrometric analysis of lipid-protein adducts to map interaction networks in cellular signaling.
• Drug Discovery Screening: Serves as a critical tool in identifying novel drug targets that function at the lipid membrane interface.
• Model Membrane Studies: Incorporation into liposomes or supported lipid bilayers (SLBs) to create functionalized membranes for biophysical assays.
• Chemical Biology Probes: Acts as a key reagent in developing activity-based probes to study enzymology of lipid-modifying enzymes.

Basic Information

Product Name	1-Palmitoyl-2-(10-(4-((Trifluoro-Methyl)Diazirinyl)Phenyl)-9-Oxaundecanoyl)-Sn-Glycero-3-Phosphocholine
CAS No.	124199-66-2
Molecular Formula	C₄₆H₇₃F₃N₃O₉P
Molecular Weight	900.06 g/mol
Synonyms	PC(Diazirine-PE); TPD-PC; Photoactivatable Phosphatidylcholine; 1-Palmitoyl-2-{10-[4-(3-Trifluoromethyl-3H-diazirin-3-yl)phenyl]-9-oxaundecanoyl}-sn-glycero-3-phosphocholine; Diazirine-Modified Phospholipid; TPD-PC (Trifluoromethyl Phenyldiazirine Phosphatidylcholine); Photo-leucine Phospholipid Analog; Membrane Cross-linking Lipid
EINECS	Contact for details

Quality Control

This high-value biochemical is manufactured under strict quality control protocols to ensure batch-to-batch consistency and functional reliability. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm structural identity, purity, and photoactivity. A comprehensive Certificate of Analysis (COA) detailing purity, functional assay results, and storage stability is provided with every shipment. Our quality system supports research requiring GMP-grade materials for critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. The product is strictly light-sensitive and must be handled under subdued light or in amber glass vials to prevent premature activation of the diazirine group. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 98% of theoretical
Photoactivation Efficiency	Contact for details
Solubility	Soluble in chloroform, methanol, DMSO
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.