Description

N(Alpha)-Benzoyl-Arginyl-Glycyl-Phenylalanyl-Prolyl-Methoxy-β-Naphthylamide is a synthetic peptide substrate designed for enzymatic research and diagnostic applications. This compound is critical for the specific detection and quantification of protease activity, particularly for enzymes like trypsin and related serine proteases. It is an essential tool for researchers and manufacturers in the fields of biochemistry, pharmaceutical development, and clinical diagnostics who require precise, high-purity substrates for assay development and quality control.

Application

• Protease Activity Assays: Primary substrate for the fluorometric or colorimetric detection and kinetic study of trypsin, thrombin, and other arginine-specific proteases.
• Diagnostic Kit Manufacturing: A key component in the production of in-vitro diagnostic (IVD) kits for measuring pancreatic function and other clinical parameters related to protease levels.
• Pharmaceutical Research & Development: Used in high-throughput screening (HTS) to identify and characterize novel protease inhibitors for drug discovery programs.
• Biochemical Research: Essential for studying enzyme mechanisms, specificity, and inhibition constants in academic and industrial laboratory settings.
• Quality Control in Bioprocessing: Employed to monitor and validate the activity of protease enzymes used in biomanufacturing processes.

Basic Information

Product Name	N(Alpha)-Benzoyl-Arginyl-Glycyl-Phenylalanyl-Prolyl-Methoxy-β-Naphthylamide
CAS No.	123712-62-9
Molecular Formula	C45H56N10O8
Molecular Weight	865.0 g/mol
Synonyms	Benzoyl-Arg-Gly-Phe-Pro-4-Methoxy-β-Naphthylamide; Bz-Arg-Gly-Phe-Pro-4MβNA; Bz-R-G-F-P-4MβNA; Trypsin Substrate (Fluorogenic); Protease Substrate 123712-62-9; Boc-Arg-Gly-Phe-Pro-AMC (related analog); Nα-Benzoyl-L-arginyl-glycyl-L-phenylalanyl-L-prolyl-4-methoxy-2-naphthylamide
EINECS	Contact for details

Quality Control

Our N(Alpha)-Benzoyl-Arginyl-Glycyl-Phenylalanyl-Prolyl-Methoxy-β-Naphthylamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive assays. Each lot undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, water content, and specific activity are provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Specific Optical Rotation	Contact for details
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.