Description

11-Oxotetrodotoxin is a potent neurotoxin derivative and a key analog of tetrodotoxin (TTX), a compound of significant pharmacological and biochemical interest. This high-purity reference standard is critical for advanced research into sodium channel function, neurophysiology, and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical testing facilities specializing in neurotoxicology and marine biotoxin studies.

Application

• Pharmacological Research: As a selective sodium channel (Nav) blocker for studying channel gating mechanisms, neuronal signaling, and action potential propagation.
• Neuroscience Tool Compound: Used in electrophysiology experiments (e.g., patch-clamp) to isolate and characterize specific sodium channel currents in neuronal and cardiac tissues.
• Analytical Reference Standard: Serves as a certified standard for the identification and quantification of tetrodotoxin analogs in complex matrices via HPLC, LC-MS, or other analytical techniques.
• Toxicology Studies: Employed in safety assessments and mechanistic studies related to marine and pufferfish poisoning (tetrodotoxin poisoning).
• Drug Discovery: A valuable molecular probe for screening and developing new analgesics, anesthetics, or neuroprotective agents that target voltage-gated sodium channels.
• Biochemical Assay Development: Used to validate and calibrate assays designed to detect sodium channel activity or inhibition.

Basic Information

Product Name	11-Oxotetrodotoxin
CAS No.	123665-88-3
Molecular Formula	C11H17N3O9
Molecular Weight	335.27 g/mol
Synonyms	11-Oxo-TTX; 11-Oxotetrodotoxin; Tetrodotoxin 11-one; 4,9-Anhydro-11-oxo-12a-homopentacyclo[5.5.2.02,6.03,10.05,9]tetradecane-8,11a-diol, 10-(hydroxymethyl)-1,2,3,3a,4,5,7,8,10,11,11a,12-dodecahydro-6H-1,8-dioxa-6a-aza-cyclopenta[a]cyclopropa[f]cyclodecen-4-one; 11-Ketotetrodotoxin
EINECS	Contact for details

Quality Control

Our 11-Oxotetrodotoxin is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.