Description

Bis-Peg11-Nhs Ester CAS NO 123502-57-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) crosslinker featuring an amine-reactive N-hydroxysuccinimide (NHS) ester at each terminus. This compound is engineered to facilitate the stable conjugation of biomolecules, such as proteins, peptides, and antibodies, with other functional entities or surfaces. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, diagnostics, and advanced drug delivery systems, where precise and reliable crosslinking is paramount.

Application

• Bioconjugation Reagent: For creating stable amide bonds between amine-containing biomolecules (e.g., antibodies, proteins) and other functional groups, surfaces, or particles.
• PEGylation Linker: Used to attach PEG chains to therapeutic proteins and peptides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Diagnostic Assay Development: Critical for labeling detection antibodies or antigens with enzymes, fluorophores, or haptens in ELISA, lateral flow assays, and other immunoassays.
• Surface Functionalization: Enables the covalent attachment of biomolecules to sensor chips, nanoparticles, microplates, and other solid supports for biosensing and microarray applications.
• Drug Delivery System Fabrication: Serves as a key building block in constructing antibody-drug conjugates (ADCs) and other targeted nanoparticle-based delivery platforms.
• Hydrogel and Biomaterial Crosslinking: Used to crosslink amine-functionalized polymers to create hydrogels and scaffolds for tissue engineering and controlled release.

Basic Information

Product Name	Bis-Peg11-Nhs Ester
CAS No.	123502-57-8
Molecular Formula	C58H96N4O30
Molecular Weight	1329.4 g/mol
Synonyms	Bis(NHS)PEG11; Bis(succinimidyl) undecaethyleneglycol ester; α,ω-Bis-[N-succinimidyloxycarbonyl]-undeca(ethylene glycol); NHS-PEG11-NHS; Bis-NHS-PEG11; PEG-11 bis(N-succinimidyl succinate); 1,11-Bis[(2,5-dioxopyrrolidin-1-yl)oxy]-1,11-dioxo-3,6,9-trioxa-2,10-diazaundecane (polyethylene glycol derivative)
EINECS	Contact for details

Quality Control

Our Bis-Peg11-Nhs Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance. Each lot is characterized using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and functional integrity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality management system is designed to meet the rigorous demands of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and the NHS ester groups are susceptible to hydrolysis. For long-term stability, store in a freezer and allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Keep the container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Substitution	> 90%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.