Description

Zatosetron Maleate CAS NO 123482-23-5 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is a selective serotonin 5-HT3 receptor antagonist, making it a critical component in the development of antiemetic medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the synthesis of novel therapeutics for nausea and vomiting control.

Application

• Pharmaceutical API Synthesis: Key intermediate in the production of 5-HT3 receptor antagonist drugs.
• Antiemetic Drug Development: Core active ingredient for medications targeting chemotherapy-induced and postoperative nausea and vomiting (CINV & PONV).
• Neurological Research: Used as a reference standard and tool compound in serotonin receptor pathway studies.
• Preclinical & Clinical Trials: Serves as the bulk drug substance for formulation into dosage forms for testing.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale manufacturing of final drug products.
• Analytical Reference Standard: Used in HPLC, LC-MS, and other analytical methods for quality control and method validation.

Basic Information

Product Name	Zatosetron Maleate
CAS No.	123482-23-5
Molecular Formula	C20H23N3O5
Molecular Weight	385.42 g/mol
Synonyms	Zatosetron hydrogen maleate; (endo)-N-(9-Methyl-9-azabicyclo[3.3.1]non-3-yl)-1H-indazole-3-carboxamide maleate; LY 277359 maleate; 1H-Indazole-3-carboxamide, N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, (Z)-2-butenedioate (1:1); Zatosetron (Maleate)
EINECS	Contact for details

Quality Control

Our Zatosetron Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed-upon standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.