Description

Zatosetron CAS NO 123482-22-4 is a selective serotonin 5-HT3 receptor antagonist. This compound is significant for its role in the research and development of antiemetic pharmaceuticals, targeting pathways associated with nausea and vomiting. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced antiemetic drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies of serotonin receptor subtypes.
• Preclinical Development: Employed in the formulation and testing stages for new therapeutic entities targeting chemotherapy-induced nausea and vomiting (CINV).
• Academic Research: Facilitates studies in neurochemistry and gastroenterology to understand emetic pathways and receptor mechanisms.
• Process Chemistry: Acts as a critical intermediate for process optimization and scale-up activities in GMP manufacturing environments.

Basic Information

Product Name	Zatosetron
CAS No.	123482-22-4
Molecular Formula	C19H21N3O2
Molecular Weight	323.39 g/mol
Synonyms	Zatosetron; 123482-22-4; 1H-Indole-3-carboxylic acid, 1-methyl-5-[[(2-methyl-1H-imidazol-1-yl)carbonyl]amino]-, ethyl ester; Ethyl 1-methyl-5-[[(2-methyl-1H-imidazol-1-yl)carbonyl]amino]-1H-indole-3-carboxylate; LY 277359; LY-277359
EINECS	Contact for details

Quality Control

Our Zatosetron is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.