Description

8-Bromoadenosine-3',5'-Cyclic Monophosphate Sodium Salt Hydrate is a chemically modified, cell-permeable analog of the ubiquitous second messenger cAMP. This compound is a crucial research tool in molecular biology and pharmacology, specifically designed to activate protein kinase A (PKA) pathways while offering enhanced stability and membrane permeability compared to its native counterpart. It is primarily utilized by researchers and pharmaceutical developers in academic institutions, biotechnology firms, and contract research organizations (CROs) for studying cellular signaling, gene expression, and metabolic regulation.

Application

• Biochemical Research: As a potent and stable activator of Protein Kinase A (PKA) for investigating cAMP-mediated signal transduction pathways.
• Cell Biology Studies: Used to examine the effects of PKA activation on cellular processes such as differentiation, proliferation, and apoptosis in various cell lines.
• Pharmacology & Drug Discovery: Serves as a reference compound and tool for screening and validating novel therapeutics targeting the adenylate cyclase or phosphodiesterase systems.
• Neuroscience Research: Applied in studies of neuronal function, synaptic plasticity, and memory formation where cAMP-PKA signaling plays a central role.
• Metabolic Disorder Research: Utilized in models to understand the regulation of glycogen, lipid, and glucose metabolism by hormonal signals.
• Enzyme Kinetics: Acts as a substrate or modulator in enzymatic assays to study the kinetics and inhibition of phosphodiesterases.

Basic Information

Item	Detail
Product Name	8-Bromoadenosine-3',5'-Cyclic Monophosphate Sodium Salt Hydrate
CAS No.	123334-12-3
Molecular Formula	C10H11BrN5NaO6P · xH2O
Molecular Weight	Contact for details
Synonyms	8-Bromo-cAMP Sodium Salt; 8-Br-cAMP Sodium Salt; 8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt; Sodium 8-bromoadenosine 3',5'-cyclic monophosphate hydrate; 8-Br-cyclic AMP sodium salt; 8-Bromo-cyclic adenosine monophosphate sodium salt; 8-Bromoadenosine cyclic 3',5'-(hydrogen phosphate) sodium salt
EINECS	Contact for details

Quality Control

Our 8-Bromoadenosine-3',5'-Cyclic Monophosphate Sodium Salt Hydrate is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	Contact for details
Heavy Metals	< 20 ppm
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.