Description

D-Fructose 2,6-Diphosphate, Sodium Salt Hydrate is a high-purity biochemical reagent and a critical phosphorylated sugar derivative. This compound serves as a potent allosteric activator of phosphofructokinase-1 (PFK-1), playing a central role in the regulation of glycolysis and gluconeogenesis. It is essential for researchers in biochemistry, enzymology, and metabolic pathway analysis, as well as for manufacturers of diagnostic kits and enzyme substrates.

Application

• Biochemical Research: Critical substrate and effector for studying the regulation of carbohydrate metabolism, glycolysis, and gluconeogenesis pathways.
• Enzyme Kinetics & Assay Development: Used as a key activator in in vitro assays for phosphofructokinase-1 (PFK-1) activity and inhibition studies.
• Diagnostic Reagent Manufacturing: A vital component in the formulation of high-sensitivity diagnostic kits for metabolic disorders and enzymatic function tests.
• Pharmaceutical Intermediates: Serves as a sophisticated starting material or intermediate in the synthesis of specialized pharmaceutical compounds targeting metabolic pathways.
• Cell Culture & Metabolism Studies: Applied in cell-based research to investigate the effects of glycolytic flux and energy metabolism under various physiological and pathological conditions.
• Reference Standard: Used as a certified reference material (CRM) for quality control and calibration in analytical laboratories.

Basic Information

Product Name	D-Fructose 2,6-Diphosphate, Sodium Salt Hydrate
CAS No.	123333-75-5
Molecular Formula	C6H11O12P2Na3·xH2O
Molecular Weight	406.04 (Anhydrous basis)
Synonyms	Fructose 2,6-Bisphosphate Sodium Salt; F2,6BP Sodium Salt; D-Fructose-2,6-bisphosphate Trisodium Salt Hydrate; Fru-2,6-P2 Na Salt; 2,6-Di-O-phosphono-D-fructose Trisodium Salt; 6-O-Phosphono-2-O-phosphono-D-fructose Trisodium Salt; β-D-Fructofuranose 2,6-bis(dihydrogen phosphate) trisodium salt
EINECS	Contact for details

Quality Control

Our D-Fructose 2,6-Diphosphate, Sodium Salt Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR). Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided to ensure compliance with research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption. For extended storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 10.0%
pH (5% Solution)	6.0 - 8.0
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.