Description

Clofarabine is a synthetic purine nucleoside analog and antimetabolite with potent antineoplastic activity. Its primary value lies in its targeted mechanism of action, which inhibits DNA synthesis and induces apoptosis in rapidly dividing cells. This makes it a critical active pharmaceutical ingredient (API) for the formulation of chemotherapeutic drugs, specifically indicated for the treatment of relapsed or refractory acute lymphoblastic leukemia (ALL) in pediatric patients. Pharmaceutical manufacturers and advanced research institutions globally rely on high-purity Clofarabine for drug development and production.

Application

• Oncological Drug Manufacturing: Primary use as the active pharmaceutical ingredient (API) in injectable formulations for chemotherapy.
• Pediatric Leukemia Treatment: Specifically formulated for treating relapsed or refractory acute lymphoblastic leukemia (ALL) in children and young adults.
• Clinical Research: Utilized in preclinical and clinical studies to investigate its efficacy against other hematologic malignancies and solid tumors.
• Pharmaceutical Development: Serves as a reference standard and key intermediate in the development of novel nucleoside-based anticancer therapies.
• Biochemical Research: Used as a tool compound to study mechanisms of DNA synthesis inhibition, ribonucleotide reductase activity, and apoptosis induction.

Basic Information

Product Name	Clofarabine
CAS No.	123318-82-1
Molecular Formula	C10H11ClFN5O3
Molecular Weight	303.68 g/mol
Synonyms	2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine; Cl-F-ara-A; Clofarex; Clolar (Brand Name); Evoltra (Brand Name); 2-Chloro-2'-fluoro-2'-deoxyarabinosyladenine; 2-Chloro-2'-fluoro-2'-deoxy-9-β-D-arabinofuranosyladenine
EINECS	Contact for details

Quality Control

Our Clofarabine is manufactured under strict cGMP conditions to ensure the highest standards of purity and consistency required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, residual solvent analysis, and stringent microbiological controls. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing compliance with in-house specifications aligned with major pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.